Why are we Still Dialyzing Overdoses to Tricyclic Antidepressants? A subanalysis of the NPDS database

Semin Dial. 2016 Sep;29(5):403-9. doi: 10.1111/sdi.12520. Epub 2016 Aug 4.


A recent analysis of the American Association of Poison Control Centers database, showed that poisonings from toxins not usually considered amenable to extracorporeal purification ("non-classic toxins" such as ethanol and tricyclic antidepressants) continue to be reported. This publication investigates factors that may explain these findings. Our results suggest that: 1) the relatively high absolute number of ECTR performed for non-classic toxins may simply reflect the large number of exposures to these toxins, 2) poisoning from another toxin may have been the reason for ECTR initiation in some exposures to non-classic toxins, 3) poisoning from non-classic toxins may receive ECTR for purposes other than toxin removal, and 4) the decisional threshold to initiate ECTR may be lower for non-classic toxins because of heightened toxicity.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents, Tricyclic / poisoning*
  • Databases, Factual
  • Hemoperfusion*
  • Humans
  • Poison Control Centers
  • Poisoning / therapy*


  • Antidepressive Agents, Tricyclic