Fungemia Caused by Candida Species and Torulopsis Glabrata in the Hospitalized Patient: Frequency, Characteristics, and Evaluation of Factors Influencing Outcome

Rev Infect Dis. May-Jun 1989;11(3):379-90. doi: 10.1093/clinids/11.3.379.


We reviewed 135 cases of candidemia occurring between 1983 and 1986 to examine oncologic and nononcologic populations and assess factors for survival. Candida albicans was the most common species (51%); Candida tropicalis occurred most frequently in leukemia patients (57%), whereas Candida parapsilosis and Torulopsis glabrata were associated with solid tumors and nononcologic diseases. Risk factors identified were: preceding surgery, antibiotics, cannulas, and steroids in solid tumor and nononcologic diseases; and chemotherapy and neutropenia with hematologic malignancies. Even transient cannula-associated candidemia was not a benign process. Intravenous cannulas were common portals of entry (39%) in debilitated patients without cancer (59%) and were associated with high mortality (55%). Overall mortality was 59%, candidemia directly contributing to death in 75% of cases. In patients with candidemia, failure to initiate therapy with amphotericin B had a negative influence on outcome, whereas analysis of the entire group identified severity of underlying illness as the dominant cofactor influencing outcome.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antifungal Agents / therapeutic use
  • Candidiasis / complications
  • Candidiasis / drug therapy
  • Candidiasis / epidemiology*
  • Catheters, Indwelling
  • Cross Infection / complications
  • Cross Infection / drug therapy
  • Cross Infection / epidemiology*
  • Female
  • Humans
  • Leukemia / complications
  • Lymphoma / complications
  • Male
  • Middle Aged
  • Neoplasms / complications
  • Neutropenia / complications
  • Postoperative Complications / blood
  • Prognosis
  • Regression Analysis
  • Retrospective Studies
  • Risk Factors
  • Sepsis / epidemiology*


  • Antifungal Agents