Risk factors for coronary artery disease and acute coronary syndrome in patients ≤40 years old

Future Cardiol. 2016 Sep;12(5):545-52. doi: 10.2217/fca-2016-0011. Epub 2016 Aug 5.


Objective: In this study, we assessed the risk factor profile in premature coronary artery disease (CAD) and acute coronary syndrome for adults ≤40 years old.

Methods: A retrospective chart analysis of 397 patients ≤40 years old admitted from 2005 to 2014 for chest pain and who underwent coronary arteriography.

Results: Of 397 patients that had undergone coronary arteriography, 54% had CAD while 46% had normal coronary arteries. When compared with patients with normal coronary arteries, patients with CAD were more likely to smoke tobacco, have dyslipidemia, be diabetic, have BMI >30 kg/m(2), have a family history of premature CAD and be male in gender.

Conclusion: Healthcare intervention in the general population through screening, counseling and education regarding the risk factors is warranted to reduce premature CAD.

Keywords: acute coronary syndrome; coronary artery disease; young adults.

MeSH terms

  • Acute Coronary Syndrome / diagnostic imaging
  • Acute Coronary Syndrome / etiology*
  • Adult
  • Age Factors
  • Body Mass Index
  • Coronary Angiography / statistics & numerical data
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / etiology*
  • Diabetic Angiopathies / etiology
  • Dyslipidemias / complications
  • Family Health
  • Female
  • Humans
  • Male
  • Retrospective Studies
  • Risk Factors
  • Smoking / adverse effects