From Krebs to clinic: glutamine metabolism to cancer therapy

Nat Rev Cancer. 2016 Oct;16(10):619-34. doi: 10.1038/nrc.2016.71. Epub 2016 Jul 29.


The resurgence of research into cancer metabolism has recently broadened interests beyond glucose and the Warburg effect to other nutrients, including glutamine. Because oncogenic alterations of metabolism render cancer cells addicted to nutrients, pathways involved in glycolysis or glutaminolysis could be exploited for therapeutic purposes. In this Review, we provide an updated overview of glutamine metabolism and its involvement in tumorigenesis in vitro and in vivo, and explore the recent potential applications of basic science discoveries in the clinical setting.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Citric Acid Cycle*
  • Glutamine / metabolism*
  • Glutarates / metabolism
  • Humans
  • Neoplasms / therapy*


  • Glutarates
  • Glutamine
  • Adenosine Triphosphate
  • glutaric acid