Antidotal Effects of Curcumin Against Agents-Induced Cardiovascular Toxicity

Cardiovasc Hematol Disord Drug Targets. 2016;16(1):30-37. doi: 10.2174/1871529x16666160802144510.

Abstract

Curcumin, the major phenolic compound in turmeric, shows preventive effects in various diseases. Curcumin is commonly found in rhizome of the Curcuma species and traditionally used in herbal medicine. Numeros studies has indicated that curcumin posses protective effects against toxic agents in various systems including cardiovascular. This study found that curcumin may be effective in cardiovascular diseases induced by toxic agents including Streptozotocin, Doxorubicin, Cyclosporin A, Methotrexate, Isoproterenol, Cadmium, Diesel exhaust particle, Nicotine, Hydrogen peroxide, and tert- Butyl hydroperoxide. However, due to the lake of information on human, further studies are needed to determine the efficacy of curcumin as an antidote agent. The present study aimed to critically review the recent literature data from that regarding the protective effects of curcumin against agents-induced cardiovascular toxicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Antidotes / chemistry
  • Antidotes / pharmacology
  • Antidotes / therapeutic use
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Cardiotonic Agents / chemistry
  • Cardiotonic Agents / pharmacology
  • Cardiotonic Agents / therapeutic use*
  • Cardiovascular Diseases / chemically induced*
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Curcuma / chemistry
  • Curcumin / chemistry
  • Curcumin / pharmacology
  • Curcumin / therapeutic use*
  • Heart / drug effects*
  • Humans
  • Myocardium / metabolism
  • Myocardium / pathology
  • Oxidative Stress / drug effects

Substances

  • Antidotes
  • Antioxidants
  • Cardiotonic Agents
  • Curcumin