An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment

J Immunol Res. 2016:2016:8426874. doi: 10.1155/2016/8426874. Epub 2016 Jul 14.

Abstract

Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, such as Alzheimer's disease, atherosclerosis, heart disease, type II diabetes, and cancer. Mounting studies have focused on the role of inflamm-aging in disease progression and many advances have been made in the last decade. However, the underlying mechanisms by which inflamm-aging affects pathological changes and disease development are still unclear. Here, we review studies of inflamm-aging that explore the concept, pathological features, mechanisms, intervention, and the therapeutic strategies of inflamm-aging in disease progression.

Publication types

  • Review

MeSH terms

  • Aging*
  • Animals
  • Biomarkers
  • Cytokines / metabolism
  • Disease Susceptibility
  • Humans
  • Inflammation / etiology*
  • Inflammation / prevention & control*
  • Inflammation / therapy*
  • Oxidation-Reduction
  • Research
  • Signal Transduction
  • Stress, Physiological

Substances

  • Biomarkers
  • Cytokines