Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor

Bull Exp Biol Med. 2016 Jul;161(3):425-9. doi: 10.1007/s10517-016-3430-2. Epub 2016 Aug 6.


We studied the relationship between microcirculation parameters and functional status of HepaRG cells in spheroids and chose an optimal regimen within the physiologically permissible limits of mechanical impact for the cells that maintains the expression of functional genes of the liver.

Keywords: HepaRG spheroids; liver-on-a-chip; microcirculation.

MeSH terms

  • Bioreactors
  • Cell Survival / physiology
  • Hepatocytes / cytology
  • Humans
  • Liver / cytology*
  • Microcirculation / physiology