Basement membranes and autoimmune diseases

Matrix Biol. 2017 Jan;57-58:149-168. doi: 10.1016/j.matbio.2016.07.008. Epub 2016 Aug 2.

Abstract

Basement membrane components are targets of autoimmune attack in diverse diseases that destroy kidneys, lungs, skin, mucous membranes, joints, and other organs in man. Epitopes on collagen and laminin, in particular, are targeted by autoantibodies and T cells in anti-glomerular basement membrane glomerulonephritis, Goodpasture's disease, rheumatoid arthritis, post-lung transplant bronchiolitis obliterans syndrome, and multiple autoimmune dermatoses. This review examines major diseases linked to basement membrane autoreactivity, with a focus on investigations in patients and animal models that advance our understanding of disease pathogenesis. Autoimmunity to glomerular basement membrane type IV is discussed in depth as a prototypic organ-specific autoimmune disease yielding novel insights into the complexity of anti-basement membrane immunity and the roles of genetic and environmental susceptibility.

Keywords: Anti-glomerular basement membrane; Autoimmunity; Basement membrane.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anti-Glomerular Basement Membrane Disease / genetics
  • Anti-Glomerular Basement Membrane Disease / immunology*
  • Anti-Glomerular Basement Membrane Disease / pathology
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / pathology
  • Autoantibodies / biosynthesis
  • Autoimmunity
  • Basement Membrane / immunology*
  • Basement Membrane / pathology
  • Bronchiolitis Obliterans / genetics
  • Bronchiolitis Obliterans / immunology*
  • Bronchiolitis Obliterans / pathology
  • Collagen Type IV / genetics
  • Collagen Type IV / immunology*
  • Disease Susceptibility
  • Gene Expression
  • Humans
  • Kidney Glomerulus / immunology
  • Kidney Glomerulus / pathology
  • Laminin / genetics
  • Laminin / immunology
  • Lung / immunology
  • Lung / pathology
  • Skin / immunology
  • Skin / pathology
  • Skin Diseases / genetics
  • Skin Diseases / immunology*
  • Skin Diseases / pathology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology

Substances

  • Autoantibodies
  • Collagen Type IV
  • Laminin