Perinatal BPA exposure alters body weight and composition in a dose specific and sex specific manner: The addition of peripubertal exposure exacerbates adverse effects in female mice

Reprod Toxicol. 2017 Mar;68:130-144. doi: 10.1016/j.reprotox.2016.07.020. Epub 2016 Aug 2.

Abstract

Body weight (BW) and body composition were examined in CD-1 mice exposed perinatally or perinatally and peripubertally to 0, 0.25, 2.5, 25, or 250μg BPA/kg BW/day. Our goal was to identify the BPA dose (s) and the exposure window(s) that increased BW and adiposity, and to assess potential sex differences in this response. Both perinatal exposure alone and perinatal plus peripubertal exposure to environmentally relevant levels of BPA resulted in lasting effects on body weight and body composition. The effects were dose specific and sex specific and were influenced by the precise window of BPA exposure. The addition of peripubertal BPA exposure following the initial perinatal exposure exacerbated adverse effects in the females but appeared to reduce differences in body weight and body composition between control and BPA exposed males. Some effects of BPA on body weight and body composition showed a non-linear dose response.

Keywords: Bisphenol A (BPA); Body composition; Developmental origins of adult disease; Extreme hyperactivity; Non-monotonic dose response; Obesity; Sex differences.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aging / drug effects*
  • Aging / metabolism
  • Animals
  • Benzhydryl Compounds / blood
  • Benzhydryl Compounds / toxicity*
  • Body Composition / drug effects*
  • Body Weight / drug effects*
  • Dose-Response Relationship, Drug
  • Environmental Pollutants / blood
  • Environmental Pollutants / toxicity*
  • Female
  • Male
  • Mice
  • Phenols / blood
  • Phenols / toxicity*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / chemically induced*
  • Prenatal Exposure Delayed Effects / metabolism
  • Sex Factors

Substances

  • Benzhydryl Compounds
  • Environmental Pollutants
  • Phenols
  • bisphenol A