Parkinson Disease and Dementia

J Geriatr Psychiatry Neurol. 2016 Sep;29(5):261-70. doi: 10.1177/0891988716654985.


Dementia is a frequent complication of Parkinson disease (PD) with a yearly incidence of around 10% of patients with PD. Lewy body pathology is the most important factor in the development of Parkinson disease dementia (PDD) and there is evidence for a synergistic effect with β-amyloid. The clinical phenotype in PDD extends beyond the dysexecutive syndrome that is often present in early PD and encompasses deficits in recognition memory, attention, and visual perception. Sleep disturbances, hallucinations, neuroleptic sensitivity, and fluctuations are often present. This review provides an update on current knowledge of PDD including aspects of epidemiology, pathology, clinical presentation, management, and prognosis.

Keywords: Parkinson disease dementia; dementia.

Publication types

  • Review

MeSH terms

  • Brain / pathology*
  • Dementia / diagnosis
  • Dementia / epidemiology*
  • Dementia / etiology
  • Hallucinations / etiology*
  • Humans
  • Incidence
  • Lewy Body Disease / complications*
  • Lewy Body Disease / diagnosis
  • Lewy Body Disease / psychology
  • Male
  • Parkinson Disease / complications
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / epidemiology
  • Sleep Wake Disorders* / etiology
  • Sleep Wake Disorders* / physiopathology