Introduction: The caries process has been thought to be irreversible, resulting in the permanent loss of tooth substance and eventually the development of a cavity. Recent approaches focused on application of remineralizing agents to incipient carious lesions, aim at controlling demineralization and promoting remineralization. Remineralizing agents create a supersaturated environment around the lesion; thus, preventing mineral loss and forces calcium and phosphate ions in the vacant areas.
Aim: To compare and evaluate the remineralization potential of Fluoride Varnish, CPP-ACP Paste (Casein Phosphopeptide-Amorphous Calcium Phosphate) and fTCP Paste (functionalized Tricalcium Phosphate) using confocal microscope.
Materials and methods: Two windows of 3X3mm were created on the labial cervical and incisal thirds in 60 permanent maxillary central incisors. The teeth were demineralized to create artificial caries and divided into three groups of 20 each. Group I specimens were coated with Fluoride Varnish once whereas those in CPP-ACP paste group and fTCP group were brushed for 2 minutes, twice daily for 20 and 40 days. The specimens were stored in artificial saliva during the study period and were later sectioned and observed under confocal microscope. Data obtained was statistically analyzed using Fischer's exact test, ANOVA and post-hoc Bonferroni's test.
Results: Fluoride Varnish, CPP-ACP Paste and fTCP Paste showed remineralization of artificial carious lesions at both the time intervals. Fluoride varnish showed the highest remineralization followed by CPP-ACP Paste and fTCP Paste. A statistically significant increase in remineralization potential of CPP-ACP Paste and fTCP Paste was observed at the end of 40 days as compared to 20 days.
Conclusion: Fluoride varnish showed the greatest remineralization potential of artificial carious lesions followed by CPP-ACP Paste and fTCP Paste respectively.
Keywords: Casein phosphopeptide-amorphous calcium phosphate; Demineralization; Functionalized tricalcium phosphate; Hard tissue microtome; Noninvasive; Rhodamine B.
An in vitro Comparison of Casein Phosphopeptide-Amorphous Calcium Phosphate Paste, Casein Phosphopeptide-Amorphous Calcium Phosphate Paste With Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate Varnish on the Inhibition of Demineralization and Promotion of Remineralization of EnamelPJ Thakkar et al. J Indian Soc Pedod Prev Dent 35 (4), 312-318. PMID 28914243.This study shows that CPP-ACPF varnish is effective in preventing demineralization as well as promoting remineralization of enamel. Thus, it can be used as an effective p …
Comparative Evaluation of Remineralization Potential of Casein Phosphopeptide-Amorphous Calcium Phosphate and Casein Phosphopeptide-Amorphous Calcium Phosphate Fluoride on Artificial Enamel White Spot Lesion: An in Vitro Light Fluorescence StudyR Mehta et al. Indian J Dent Res 24 (6), 681-9. PMID 24552927.
As compared with artificial saliva both CPP-ACP and CPP-ACFP produced significant amount of remineralization of the artificial enamel white spot lesion (P < 0.001), ho…
Efficacy of Calcium- And Fluoride-Containing Materials for the Remineralization of Primary Teeth With Early Enamel LesionM Memarpour et al. Microsc Res Tech 78 (9), 801-6. PMID 26179280.The aim of the study was to determine the efficacy of different products containing fluoride, calcium and phosphate for enamel remineralization in eroded primary teeth. A …
Anticariogenicity of Casein Phosphopeptide-Amorphous Calcium Phosphate: A Review of the LiteratureC Llena et al. J Contemp Dent Pract 10 (3), 1-9. PMID 19430620. - ReviewRemineralization of white spot lesions has been achieved clinically by applying pastes based on these compounds, and a similar effect to self-applied fluorides has been o …
Recent Advances in Dental Hard Tissue Remineralization: A Review of LiteratureMK Arifa et al. Int J Clin Pediatr Dent 12 (2), 139-144. PMID 31571787. - ReviewArifa MK, Ephraim R, et al. Recent Advances in Dental Hard Tissue Remineralization: A Review of Literature. Int J Clin Pediatr Dent 2019;12(2):139-144.
Cited by 4 PubMed Central articles
Effect of the Casein Phosphopeptide-Amorphous Calcium Phosphate Fluoride (CPP-ACPF) and Photobiomodulation (PBM) on Dental Hypersensitivity: A Randomized Controlled Clinical TrialMI Guanipa Ortiz et al. PLoS One 14 (12), e0225501. PMID 31790452.After one-month follow-up, the association of CPP-ACPF with PBM was effective in the reduction of DH and promoted a positive impact on the HRQL of the participants of thi …
Influence of CO2 Laser Irradiation and CPPACP Paste Application on Demineralized Enamel MicrohardnessZ Khamverdi et al. J Lasers Med Sci 9 (2), 144-148. PMID 30026901.Introduction: It has been suggested that the application of casein phosphopeptide-amorphous calcium phosphate paste (CPP-ACP) and CO2 laser irradiation on enamel c …
Effect of Proanthocyanidin, Fluoride and Casein Phosphopeptide Amorphous Calcium Phosphate Remineralizing Agents on Microhardness of Demineralized DentinZ Khamverdi et al. J Dent (Tehran) 14 (2), 76-83. PMID 29104598.The results of this study showed that the tested dentin treatments increased the microhardness of demineralized root dentin except for PA application.
The Efficiency of Child Formula Dentifrices Containing Different Calcium and Phosphate Compounds on Artificial Enamel CariesP Rirattanapong et al. J Int Soc Prev Community Dent 6 (6), 559-567. PMID 28032049.All toothpastes in this study had the potential to delay the demineralization progression of artificial enamel caries in primary teeth. The fluoride 500 ppm and TCP tooth …