Regulation of myogenesis by environmental hypoxia

J Cell Sci. 2016 Aug 1;129(15):2887-96. doi: 10.1242/jcs.188904. Epub 2016 Jul 11.


In aerobic organisms, oxygen is a critical factor for tissue and organ morphogenesis from embryonic development throughout the adult life. It regulates various intracellular pathways involved in cellular metabolism, proliferation, cell survival and fate. Organisms or tissues rapidly respond to changes in oxygen availability by activating complex signalling networks, which culminate in the control of mRNA translation and/or gene expression. This Commentary presents the effects of hypoxia during embryonic development, myoblasts and satellite cell proliferation and differentiation in vertebrates. We also outline the relationship between Notch, Wnt and growth factor signalling pathways, as well as the post-transcriptional regulation of myogenesis under conditions of hypoxia.

Keywords: Hypoxia; Myogenesis; Signalling.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Hypoxia / genetics
  • Gene Expression Regulation
  • Humans
  • Muscle Development* / genetics
  • Myoblasts / metabolism
  • Myoblasts / pathology
  • Protein Biosynthesis
  • Signal Transduction / genetics