Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development

Bernd B Zeisig; Chi Wai Eric So

doi:10.1016/j.ccell.2016.07.014

Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development

Cancer Cell. 2016 Aug 8;30(2):185-187. doi: 10.1016/j.ccell.2016.07.014.

Authors

Bernd B Zeisig¹, Chi Wai Eric So²

Affiliations

¹ Division of Cancer Studies, Department of Haematological Medicine, Leukaemia and Stem Cell Biology Group, King's College London, Denmark Hill, SE5 9NU London, UK.
² Division of Cancer Studies, Department of Haematological Medicine, Leukaemia and Stem Cell Biology Group, King's College London, Denmark Hill, SE5 9NU London, UK. Electronic address: eric.so@kcl.ac.uk.

PMID: 27505665
DOI: 10.1016/j.ccell.2016.07.014

Abstract

Polycomb repressive complexes (PRCs) are key to normal development and are frequently deregulated in human cancer. In this issue of Cancer Cell, Béguelin et al. report a mechanism of non-canonical PRC1 recruitment by BCL6 in collaboration with EZH2-mediated H3K27me3 for establishment of stable repressive complexes in germinal center B cells.

Publication types

Comment

MeSH terms

B-Lymphocytes
Germinal Center*
Humans
Polycomb-Group Proteins*

Substances

Polycomb-Group Proteins

Grants and funding

16753/CRUK_/Cancer Research UK/United Kingdom