The thermogenic effects of pre- and postprandial exercise was examined in seven lean active females. Energy expenditure was measured for 3 h via open circuit indirect calorimetry after four separate treatments: Exercise Only (25 min treadmill run at 60% VO2 max), Meal Only (910 kcal mixed meal), Exercise-Meal and Meal-Exercise. The thermogenic response to the Exercise-Meal treatment was similar to the Meal Only treatment. However, the Meal-Exercise treatment resulted in a greater energy expenditure than the Meal Only and Exercise-Meal treatments. The Exercise Only treatment showed the lowest thermogenic response. These data suggest that exercise following a meal would be more beneficial than exercise before a meal in increasing and maintaining an elevated energy expenditure.