A genomic view of the peopling of the Americas

Curr Opin Genet Dev. 2016 Dec:41:27-35. doi: 10.1016/j.gde.2016.06.016. Epub 2016 Aug 6.


Whole-genome studies have documented that most Native American ancestry stems from a single population that diversified within the continent more than twelve thousand years ago. However, this shared ancestry hides a more complex history whereby at least four distinct streams of Eurasian migration have contributed to present-day and prehistoric Native American populations. Whole genome studies enhanced by technological breakthroughs in ancient DNA now provide evidence of a sequence of events involving initial migrations from a structured Northeast Asian source population with differential relatedness to present-day Australasian populations, followed by a divergence into northern and southern Native American lineages. During the Holocene, new migrations from Asia introduced the Saqqaq/Dorset Paleoeskimo population to the North American Arctic ∼4500 years ago, ancestry that is potentially connected with ancestry found in Athabaskan-speakers today. This was then followed by a major new population turnover in the high Arctic involving Thule-related peoples who are the ancestors of present-day Inuit. We highlight several open questions that could be addressed through future genomic research.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Americas
  • Arctic Regions
  • Asia
  • Genome, Human*
  • Genomics*
  • History, Ancient
  • Human Migration*
  • Humans
  • Indians, North American / genetics*
  • Indians, North American / history
  • North America