Transporters affecting biochemical test results: Creatinine-drug interactions

Clin Pharmacol Ther. 2016 Nov;100(5):437-440. doi: 10.1002/cpt.445. Epub 2016 Sep 15.

Abstract

Creatinine is eliminated by the kidneys through a combination of glomerular filtration and active transport. Drug-induced increases in serum creatinine (SCr) and/or reduced creatinine renal clearance are used as a marker for acute kidney injury. However, inhibition of active transport of creatinine can result in reversible and, therefore, benign increases in SCr levels. Herein, the transporters involved in creatinine clearance are discussed, in addition to limitations of using creatinine as a biomarker for kidney damage.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / blood*
  • Acute Kidney Injury / diagnosis
  • Animals
  • Biomarkers / blood
  • Creatinine / blood*
  • Drug-Related Side Effects and Adverse Reactions / blood*
  • Humans
  • Models, Biological
  • Organic Cation Transport Proteins / drug effects
  • Organic Cation Transport Proteins / metabolism*

Substances

  • Biomarkers
  • Organic Cation Transport Proteins
  • Creatinine