Bacterial Stress Responses during Host Infection

Cell Host Microbe. 2016 Aug 10;20(2):133-43. doi: 10.1016/j.chom.2016.07.009.


Pathogenic bacteria must withstand diverse host environments during infection. Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger adaptive responses within bacteria to these specific stress conditions but also direct the expression of virulence genes at an appropriate time and place. An appreciation of stress responses and their regulation is therefore essential for an understanding of bacterial pathogenesis. This review considers specific stresses in the host environment and their relevance to pathogenesis, with a particular focus on the enteric pathogen Salmonella.

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological*
  • Gene Expression Regulation, Bacterial
  • Host-Pathogen Interactions*
  • Salmonella / pathogenicity*
  • Salmonella / physiology*
  • Salmonella Infections / immunology
  • Salmonella Infections / microbiology
  • Stress, Physiological*
  • Virulence Factors / biosynthesis


  • Virulence Factors