Discrimination and Integration of Stress Signals by Pathogenic Bacteria

Cell Host Microbe. 2016 Aug 10;20(2):144-153. doi: 10.1016/j.chom.2016.07.010.


For pathogenic bacteria, the ability to sense and respond to environmental stresses encountered within the host is critically important, allowing them to adapt to changing conditions and express virulence genes appropriately. This review considers the diverse molecular mechanisms by which stress conditions are sensed by bacteria, how related signals are discriminated, and how stress responses are integrated, highlighting recent studies in selected bacterial pathogens of clinical relevance.

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological*
  • Bacterial Physiological Phenomena
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism
  • Host-Pathogen Interactions*
  • Signal Transduction*
  • Stress, Physiological*


  • Bacterial Proteins