The association between blood pressure and lipid levels in Europe: European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice

J Hypertens. 2016 Nov;34(11):2155-63. doi: 10.1097/HJH.0000000000001078.

Abstract

Objectives: Several studies have suggested a positive association between serum lipid levels and blood pressure (BP). This study investigated this association in a large population from 12 European countries.

Methods: Data were taken from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice (ClinicalTrials.gov identifier: NCT00882336). Associations between BP and lipid levels in patients free from cardiovascular disease and with at least one major cardiovascular disease risk factor (N = 7641) were assessed using linear regression analyses.

Results: Overall, 72.8 and 64.8% of patients had hypertension and dyslipidaemia, respectively; 47.0% had both conditions. Regression coefficients (95% confidence interval) for the associations of LDL cholesterol, non-HDL cholesterol, total cholesterol and apolipoprotein B levels with SBP, adjusted for age, sex and BMI, were 0.93 mmHg/mmol per l (0.54-1.31), 1.07 mmHg/mmol per l (0.73-1.40), 1.02 mmHg/mmol per l (0.69-1.35) and 4.94 mmHg/g per l (3.43-6.46), respectively. The corresponding values (95% confidence interval) for the associations with DBP were 0.96 mmHg/mmol per l (0.73-1.19), 0.95 mmHg/mmol per l (0.75-1.15), 0.87 mmHg/mmol per l (0.67-1.07) and 4.33 mmHg/g per l (3.42-5.23), respectively. Most of these associations remained significant whether patients were treated with statins or not.

Conclusion: Small but statistically significant associations between lipid levels and BP were observed in a large, multinational European population. Further research is warranted to assess the causality of this association and its implications on the management of patients with both hypertension and dyslipidaemia.

MeSH terms

  • Adult
  • Aged
  • Apolipoproteins B / blood
  • Blood Pressure*
  • Cholesterol / blood*
  • Cholesterol, LDL / blood
  • Diastole
  • Dyslipidemias / blood*
  • Dyslipidemias / complications*
  • Europe
  • Female
  • Humans
  • Hypertension / blood*
  • Hypertension / complications*
  • Male
  • Middle Aged
  • Systole
  • White People

Substances

  • Apolipoproteins B
  • Cholesterol, LDL
  • Cholesterol

Associated data

  • ClinicalTrials.gov/NCT00882336