Adverse Effects of Psychotropic Medications on Sleep

Psychiatr Clin North Am. 2016 Sep;39(3):487-502. doi: 10.1016/j.psc.2016.04.009. Epub 2016 Jun 24.


Psychotropic medications such as antidepressants, antipsychotics, stimulants, and benzodiazepines are widely prescribed. Most of these medications are thought to exert their effects through modulation of various monoamines as well as interactions with receptors such as histamine and muscarinic cholinergic receptors. Through these interactions, psychotropics can also have a significant impact on sleep physiology, resulting in both beneficial and adverse effects on sleep.

Keywords: Adverse effects; Antidepressant; Antipsychotic; Insomnia; Sedation; Sleep; Somnolence.

Publication types

  • Review

MeSH terms

  • Humans
  • Psychotropic Drugs / adverse effects*
  • Sleep Wake Disorders / chemically induced*
  • Sleep Wake Disorders / drug therapy*


  • Psychotropic Drugs