Imprinting and recalling cortical ensembles

Science. 2016 Aug 12;353(6300):691-4. doi: 10.1126/science.aaf7560. Epub 2016 Aug 11.

Abstract

Neuronal ensembles are coactive groups of neurons that may represent building blocks of cortical circuits. These ensembles could be formed by Hebbian plasticity, whereby synapses between coactive neurons are strengthened. Here we report that repetitive activation with two-photon optogenetics of neuronal populations from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontaneously after being imprinted and do not disrupt preexisting ones. Moreover, imprinted ensembles can be recalled by single- cell stimulation and remain coactive on consecutive days. Our results demonstrate the persistent reconfiguration of cortical circuits by two-photon optogenetics into neuronal ensembles that can perform pattern completion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials
  • Animals
  • Imprinting, Psychological*
  • Male
  • Mental Recall*
  • Mice
  • Mice, Inbred C57BL
  • Neuronal Plasticity
  • Neurons / physiology
  • Optogenetics
  • Photic Stimulation
  • Synapses
  • Visual Cortex / cytology
  • Visual Cortex / physiology*