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Review
. 2016 Sep;30(9):1160-9.
doi: 10.1038/eye.2016.156. Epub 2016 Aug 12.

Global Prevalence of Childhood Cataract: A Systematic Review

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Free PMC article
Review

Global Prevalence of Childhood Cataract: A Systematic Review

S Sheeladevi et al. Eye (Lond). .
Free PMC article

Abstract

Childhood cataract is an avoidable cause of visual disability worldwide and is a priority for VISION 2020: The Right to Sight. There is a paucity of information about the burden of cataract in children and the aim of this review is to assess the global prevalence of childhood cataract. The methodology for the review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We performed a literature search for studies reporting estimates of prevalence or incidence of cataract among children (aged<18 years) at any global location using the Cochrane Library, Medline and Embase up to January 2015. No restrictions were imposed based on language or year of publication. Study quality was assessed using a critical appraisal tool designed for systematic reviews of prevalence. Twenty prevalence and four incidence studies of childhood cataract from five different geographical regions were included. The overall prevalence of childhood cataract and congenital cataract was in the range from 0.32 to 22.9/10000 children (median=1.03) and 0.63 to 9.74/10000 (median=1.71), respectively. The incidence ranged from 1.8 to 3.6/10000 per year. The prevalence of childhood cataract in low-income economies was found to be 0.42 to 2.05 compared with 0.63 to 13.6/10000 in high-income economies. There was no difference in the prevalence based on laterality or gender. This review highlights substantial gaps in the epidemiological knowledge of childhood cataract worldwide, particularly from low and lower middle-income economies. More studies are needed using standard definitions and case ascertainment methods with large enough sample sizes.

Figures

Figure 1
Figure 1
Quality assessment of the 24 included studies.
Figure 2
Figure 2
Summary of review strategy—PRISMA Flow Diagram.
Figure 3
Figure 3
Forest Plot on prevalence of Childhood cataract in low- and lower middle-income countries compared with high- and higher middle-income countries (proportions with 95% confidence interval). For each study, the size of the symbol corresponds to the sample size.

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