Look Out Autophagy, Ubiquilin UPS Its Game

Rachel Brown; Daniel Kaganovich

doi:10.1016/j.cell.2016.07.048

Look Out Autophagy, Ubiquilin UPS Its Game

Cell. 2016 Aug 11;166(4):797-799. doi: 10.1016/j.cell.2016.07.048.

Authors

Rachel Brown¹, Daniel Kaganovich²

Affiliations

¹ Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem 91904, Israel.
² Department of Cell and Developmental Biology, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem 91904, Israel. Electronic address: dan@cc.huji.ac.il.

PMID: 27518558
DOI: 10.1016/j.cell.2016.07.048

Abstract

Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.

Publication types

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MeSH terms

Amyotrophic Lateral Sclerosis / genetics
Autophagy
Cell Cycle Proteins / genetics
Humans
Proteasome Endopeptidase Complex / metabolism*
Ubiquitin / metabolism*
Ubiquitins / genetics

Substances

Cell Cycle Proteins
Ubiquitin
Ubiquitins
Proteasome Endopeptidase Complex