Look Out Autophagy, Ubiquilin UPS Its Game

Cell. 2016 Aug 11;166(4):797-799. doi: 10.1016/j.cell.2016.07.048.


Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.

Publication types

  • Comment

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics
  • Autophagy
  • Cell Cycle Proteins / genetics
  • Humans
  • Proteasome Endopeptidase Complex / metabolism*
  • Ubiquitin / metabolism*
  • Ubiquitins / genetics


  • Cell Cycle Proteins
  • Ubiquitin
  • Ubiquitins
  • Proteasome Endopeptidase Complex