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Editorial
. 2016 Aug 4;375(5):477-9.
doi: 10.1056/NEJMe1607438.

Innate Immunity in Asthma

Talal A Chatila  1
Affiliations
Editorial

Innate Immunity in Asthma

Talal A Chatila. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1
Farming Lifestyle, the Activation of Innate Immunity, and Protection against Asthma. Differences in the prevalence of asthma and allergic sensitization in Amish and Hutterite communities are linked to their distinct farming practices. The traditional farming practices in Amish communities protect against asthma by inducing a long-term, low-level, proinflammatory innate immune response. This protection involves the activation by microbial signals, acting through MyD88 and Trif and the production of tumor necrosis factor (TNF) and interleukin-1. The Hutterites, who practice mechanized farming and are not exposed to the same microbial influences, are not protected.
See this image and copyright information in PMC

Comment on

  • Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children.
    Stein MM, Hrusch CL, Gozdz J, Igartua C, Pivniouk V, Murray SE, Ledford JG, Marques Dos Santos M, Anderson RL, Metwali N, Neilson JW, Maier RM, Gilbert JA, Holbreich M, Thorne PS, Martinez FD, von Mutius E, Vercelli D, Ober C, Sperling AI. Stein MM, et al. N Engl J Med. 2016 Aug 4;375(5):411-421. doi: 10.1056/NEJMoa1508749. N Engl J Med. 2016. PMID: 27518660 Free PMC article.

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