Colletotrilactam A-D, novel lactams from Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla

Fitoterapia. 2016 Sep:113:158-63. doi: 10.1016/j.fitote.2016.08.005. Epub 2016 Aug 9.

Abstract

Four novel lactams, colletotrilactam A-D (1-4), along with six known compounds (5-10) were isolated from the culture broth of Colletotrichum gloeosporioides GT-7, a fungal endophyte of Uncaria rhynchophylla. The structures of these compounds were elucidated by comprehensive NMR spectroscopy. Isolates were tested for monoamine oxidase (MAO) inhibitory activity and compound 9 showed potent MAO inhibitory activity with IC50 value of 8.93±0.34μg/mL, when the IC50 value of iproniazid as a standard was 1.80±0.5μg/mL.

Keywords: Blumenol A (PubChem CID: 5280462); Colletotrichum gloeosporioides; Colletotrilactam; Hederagonic acid (PubChem CID: 12310388); Lactams; Mellein (PubChem CID: 28516); Monoamine oxidase inhibitors; Rubiaceae; Uncaria rhynchophylla; cis-4-Hydroxymellein (PubChem CID: 44445003).

MeSH terms

  • Colletotrichum / chemistry*
  • Endophytes / chemistry
  • Lactams / chemistry*
  • Lactams / isolation & purification
  • Molecular Structure
  • Monoamine Oxidase / metabolism
  • Monoamine Oxidase Inhibitors / chemistry*
  • Monoamine Oxidase Inhibitors / isolation & purification
  • Uncaria / microbiology*

Substances

  • Lactams
  • Monoamine Oxidase Inhibitors
  • Monoamine Oxidase