Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes

J Infect Dis. 2016 Oct 15;214(suppl 3):S275-S280. doi: 10.1093/infdis/jiw260. Epub 2016 Aug 11.


A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16+ monocytes with a poor activation profile. In survivors, CD16+ monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology.

Keywords: CD14; CD16; Ebola virus; Ebola virus disease; monocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendritic Cells / immunology*
  • Dendritic Cells / virology
  • Ebolavirus / immunology*
  • Ebolavirus / isolation & purification
  • Female
  • Hemorrhagic Fever, Ebola / diagnosis
  • Hemorrhagic Fever, Ebola / immunology*
  • Hemorrhagic Fever, Ebola / physiopathology
  • Hemorrhagic Fever, Ebola / virology
  • Humans
  • Kinetics
  • Mobile Health Units
  • Monocytes / immunology*
  • Monocytes / virology
  • Neutrophils / immunology*
  • Neutrophils / virology
  • Phenotype
  • Receptors, IgG / immunology*


  • Receptors, IgG