In situ microemulsion synthesis of hydroxyapatite-MgFe2O4 nanocomposite as a magnetic drug delivery system

Abstract

In this study, an innovative synthesis process has been developed to produce hydroxyapatite-magnesium ferrite (HA-MgFe2O4) nanocomposite. In addition, the effect of calcination temperature on drug delivery behavior of produced samples was investigated. HA-MgFe2O4 nanocomposite was prepared via one-step modified reverse microemulsion synthesis route. The resulting products were characterized by X-ray Diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), and Brunauer-Emmett-Teller surface area analysis (BET). The calcined samples at 500 and 700°C demonstrated mesoporous characteristics and large specific surface areas of 88 and 32m(2)/g, respectively. TEM and VSM results showed that the nanocomposite calcined at 700°C has core-shell morphology and a maximum saturation magnetization of 9.47emug(-1).

Keywords: Drug delivery; Hydroxyapatite; Ibuprofen; Magnesium ferrite; Microemulsion synthesis.