Obesity Cardiomyopathy: Pathophysiologic Factors and Nosologic Reevaluation

Am J Med Sci. 2016 Aug;352(2):219-22. doi: 10.1016/j.amjms.2016.05.014. Epub 2016 May 24.


Cardiovascular disease in populations with obesity is a major concern because of its epidemic proportion. Obesity leads to the development of cardiomyopathy directly via inflammatory mediators and indirectly by obesity-induced hypertension, diabetes and coronary artery diseases. The aim of this review article is to re-visit the available knowledge and the evidence on pathophysiologic mechanisms of obesity-related cardiomyopathy and to propose its placement into a specific category of myocardial disease.

Keywords: Heart failure; Metainflammation; Obesity cardiomyopathy; Obesity paradox.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiomyopathies / blood
  • Cardiomyopathies / epidemiology*
  • Cardiomyopathies / physiopathology*
  • Heart Failure / blood
  • Heart Failure / epidemiology*
  • Heart Failure / physiopathology*
  • Humans
  • Insulin Resistance / physiology
  • Obesity / blood
  • Obesity / epidemiology*
  • Obesity / physiopathology*