Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016;6(2):111-5.
doi: 10.15171/bi.2016.16. Epub 2016 Jul 15.

Infection-resistant MRI-visible Scaffolds for Tissue Engineering Applications

Affiliations
Free PMC article

Infection-resistant MRI-visible Scaffolds for Tissue Engineering Applications

Morteza Mahmoudi et al. Bioimpacts. .
Free PMC article

Abstract

Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium. By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies.

Keywords: Antibacterial properties; Collagen scaffold; Magnetic resonance imaging; SPION; Superparamagnetic iron oxide; Tissue engineering; nanoparticles.

Figures

Fig. 1
Fig. 1
Fig. 2
Fig. 2
Fig. 3
Fig. 3
Fig. 4
Fig. 4

Similar articles

See all similar articles

Cited by 7 articles

See all "Cited by" articles

References

    1. Serpooshan V, Zhao M, Metzler SA, Wei K, Shah PB, Wang A. et al. The effect of bioengineered acellular collagen patch on cardiac remodeling and ventricular function post myocardial infarction. Biomaterials. 2013;34:9048–55. doi: 10.1016/j.biomaterials.2013.08.017. - DOI - PMC - PubMed
    1. Karfeld-Sulzer LS, Waters EA, Kohlmeir EK, Kissler H, Zhang X, Kaufman DB. et al. Protein polymer MRI contrast agents: Longitudinal analysis of biomaterials in vivo. Biomed Eng Comput Biol. 2014;6:13–20. - PubMed
    1. Serpooshan V, Quinn TM, Muja N, Nazhat SN. Hydraulic permeability of multilayered collagen gel scaffolds under plastic compression-induced unidirectional fluid flow. Acta Biomaterialia. 2013;9:4673–80. doi: 10.1016/j.actbio.2012.08.031. - DOI - PubMed
    1. Serpooshan V, Quinn TM, Muja N, Nazhat SN. Characterization and modelling of a dense lamella formed during self-compression of fibrillar collagen gels: implications for biomimetic scaffolds. Soft Matter. 2011;7:2918–26.
    1. Kim SH, Lee JH, Hyun H, Ashitate Y, Park G, Robichaud K. et al. Near-Infrared Fluorescence Imaging for Noninvasive Trafficking of Scaffold Degradation. Sci Rep. 2013;3:749. doi: 10.1038/srep01198. - DOI - PMC - PubMed

LinkOut - more resources

Feedback