Uniting functional network topology and oscillations in the fronto-parietal single unit network of behaving primates

Elife. 2016 Aug 15:5:e15719. doi: 10.7554/eLife.15719.


The functional communication of neurons in cortical networks underlies higher cognitive processes. Yet, little is known about the organization of the single neuron network or its relationship to the synchronization processes that are essential for its formation. Here, we show that the functional single neuron network of three fronto-parietal areas during active behavior of macaque monkeys is highly complex. The network was closely connected (small-world) and consisted of functional modules spanning these areas. Surprisingly, the importance of different neurons to the network was highly heterogeneous with a small number of neurons contributing strongly to the network function (hubs), which were in turn strongly inter-connected (rich-club). Examination of the network synchronization revealed that the identified rich-club consisted of neurons that were synchronized in the beta or low frequency range, whereas other neurons were mostly non-oscillatory synchronized. Therefore, oscillatory synchrony may be a central communication mechanism for highly organized functional spiking networks.

Keywords: inter-areal communication; network topology; neural circuits; neuroscience; oscillatory synchrony; rhesus macaque; sensorimotor processing; single neuron functional connectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Cognition*
  • Frontal Lobe / anatomy & histology*
  • Frontal Lobe / physiology
  • Macaca*
  • Nerve Net*
  • Neural Pathways / anatomy & histology*
  • Neural Pathways / physiology*
  • Neurons / physiology
  • Parietal Lobe / anatomy & histology*
  • Parietal Lobe / physiology

Grants and funding

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.