Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

doi:10.1007/s11684-016-0464-9

Review

. 2016 Sep;10(3):237-49.

doi: 10.1007/s11684-016-0464-9. Epub 2016 Sep 7.

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas^{1

2}, Shasha Zhang^{1

2}, Zuhong He^{1

2}, Mingliang Tang^{3

4}, Renjie Chai^{5

6}

Affiliations

¹ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
² Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
³ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. mingliangtang@seu.edu.cn.
⁴ Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. mingliangtang@seu.edu.cn.
⁵ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.
⁶ Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. renjiec@seu.edu.cn.

PMID: 27527363
DOI: 10.1007/s11684-016-0464-9

Review

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas et al. Front Med. 2016 Sep.

. 2016 Sep;10(3):237-49.

doi: 10.1007/s11684-016-0464-9. Epub 2016 Sep 7.

Authors

Muhammad Waqas^{1

2}, Shasha Zhang^{1

2}, Zuhong He^{1

2}, Mingliang Tang^{3

4}, Renjie Chai^{5

6}

Affiliations

¹ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China.
² Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
³ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. mingliangtang@seu.edu.cn.
⁴ Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. mingliangtang@seu.edu.cn.
⁵ Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. renjiec@seu.edu.cn.
⁶ Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. renjiec@seu.edu.cn.

PMID: 27527363
DOI: 10.1007/s11684-016-0464-9

Abstract

Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.

Keywords: Notch; Wnt; cochlea; hair cell; inner ear; regeneration; signaling pathways.

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References

1. Dev Dyn. 2013 Dec;242(12):1454-65 - PubMed
1. J Biol Chem. 2010 Jan 1;285(1):392-400 - PubMed
1. Cell Cycle. 2005 Mar;4(3):373-5 - PubMed
1. Dev Dyn. 2013 Feb;242(2):179-88 - PubMed
1. Dev Neurobiol. 2014 Apr;74(4):438-56 - PubMed

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[1] Dev Dyn. 2013 Dec;242(12):1454-65 - PubMed

[2] Dev Dyn. 2013 Dec;242(12):1454-65 - PubMed

[3] J Biol Chem. 2010 Jan 1;285(1):392-400 - PubMed

[4] J Biol Chem. 2010 Jan 1;285(1):392-400 - PubMed

[5] Cell Cycle. 2005 Mar;4(3):373-5 - PubMed

[6] Cell Cycle. 2005 Mar;4(3):373-5 - PubMed

[7] Dev Dyn. 2013 Feb;242(2):179-88 - PubMed

[8] Dev Dyn. 2013 Feb;242(2):179-88 - PubMed

[9] Dev Neurobiol. 2014 Apr;74(4):438-56 - PubMed

[10] Dev Neurobiol. 2014 Apr;74(4):438-56 - PubMed

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

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