Designing Clinical Trials for Two-Sided Multiple Comparisons With a Control

Control Clin Trials. 1989 Jun;10(2):142-52. doi: 10.1016/0197-2456(89)90027-5.


When a clinical trial is to be conducted to compare more than one experimental treatment to a control treatment, Dunnett's two-sided multiple comparison procedure may be proposed to perform the analysis. During the planning stage, the problem of determining the appropriate sample size must be resolved. Here a solution to this problem is derived by controlling the power of the corresponding testing procedure that assumes that the common variance is known.

Publication types

  • Comparative Study

MeSH terms

  • Arthritis, Rheumatoid / drug therapy
  • Clinical Trials as Topic / methods*
  • Humans
  • Programming Languages
  • Research Design*
  • Sampling Studies
  • Statistics as Topic*