Intra-articular bone marrow concentrate injection protocol: short-term efficacy in osteoarthritis

Regen Med. 2016 Sep;11(6):511-20. doi: 10.2217/rme-2016-0081. Epub 2016 Aug 16.


Aim: Evaluate intra-articular injection of bone marrow concentrate (BMC), followed by platelet-rich plasma (PRP) injection at 8 weeks follow-up in moderate/severe osteoarthritis.

Design: Single center, retrospective Case Series (n = 125).

Methods: Bone marrow was aspirated/concentrated using a standardized technique. Patients received a single intra-articular injection of BMC, with follow-up injection of PRP at 8 weeks.

Results: Median absolute pain reduction in all joints was five points (71.4%) on visual analog scale. Median patient satisfaction was 9.0/10, while 91.7% indicated that they would repeat the procedure and 94% said that they would recommend the procedure to a friend.

Conclusion: Intra-articular injection of BMC, followed by a PRP injection, can provide short-term benefits in moderate-to-severe osteoarthritis.

Keywords: bone marrow concentrate; orthobiologics; osteoarthritis; platelet-rich plasma.

MeSH terms

  • Adult
  • Aged
  • Bone Marrow Cells / cytology*
  • Female
  • Humans
  • Injections, Intra-Articular / methods*
  • Male
  • Middle Aged
  • Osteoarthritis / therapy*
  • Pain / prevention & control*
  • Pain Measurement
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult