Electrochemical Oxidative C-H/N-H Coupling between γ-Lactams and Anilines

Ming Gong; Jing-Mei Huang

doi:10.1002/chem.201602454

Electrochemical Oxidative C-H/N-H Coupling between γ-Lactams and Anilines

Chemistry. 2016 Sep 26;22(40):14293-6. doi: 10.1002/chem.201602454. Epub 2016 Aug 16.

Authors

Ming Gong¹, Jing-Mei Huang²

Affiliations

¹ Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, P. R. China.
² Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong, 510640, P. R. China. chehjm@scut.edu.cn.

PMID: 27529163
DOI: 10.1002/chem.201602454

Abstract

A mild method for the direct C-H/N-H coupling between γ-lactams and anilines through electrochemical oxidation has been developed. The protocol proceeded smoothly without metal catalysts at room temperature to afford γ-substituted γ-lactams in good yields. It has been revealed that the quasi-divided cell which provided high current density on the anode was crucial for this reaction.

Keywords: C−H/N−H coupling; anilines; electrochemistry; metal free; γ-lactams.