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. 2017 Jan;71(1):286-291.
doi: 10.1007/s11418-016-1030-0. Epub 2016 Aug 16.

Cannabidiolic Acid-Mediated Selective Down-Regulation of C-Fos in Highly Aggressive Breast Cancer MDA-MB-231 Cells: Possible Involvement of Its Down-Regulation in the Abrogation of Aggressiveness

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Cannabidiolic Acid-Mediated Selective Down-Regulation of C-Fos in Highly Aggressive Breast Cancer MDA-MB-231 Cells: Possible Involvement of Its Down-Regulation in the Abrogation of Aggressiveness

Shuso Takeda et al. J Nat Med. .

Abstract

The physiological activities of cannabidiolic acid (CBDA), a component of fiber-type cannabis plants, have been demonstrated and include its function as a protector against external invasion by inducing cannabinoid-mediated necrosis (Shoyama et al., Plant Signal Behav 3:1111-1112, 2008). The biological activities of CBDA have been attracting increasing attention. We previously identified CBDA as an inhibitor of the migration of MDA-MB-231 cells, a widely used human breast cancer cell line in cancer biology, due to its highly aggressive nature. The chemical inhibition and down-regulation of cyclooxygenase-2 (COX-2), the expression of which has been detected in ~40 % of human invasive breast cancers, are suggested to be involved in the CBDA-mediated abrogation of cell migration. However, the molecular mechanism(s) responsible for the CBDA-induced down-regulation of COX-2 in MDA-MB-231 cells have not yet been elucidated. In the present study, we describe a possible mechanism by which CBDA abrogates the expression of COX-2 via the selective down-regulation of c-fos, one component of the activator protein-1 (AP-1) dimer complex, a transcription factor for the positive regulation of the COX-2 gene.

Keywords: Cannabidiolic acid; Cyclooxygenase-2; Fiber-type cannabis plant; MDA-MB-231 cells; c-fos.

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References

    1. J Biol Chem. 1997 Jan 3;272(1):601-8 - PubMed
    1. J Biol Chem. 1997 Apr 11;272(15):9962-70 - PubMed
    1. Chem Pharm Bull (Tokyo). 1967 Jul;15(7):1075-6 - PubMed
    1. Science. 1994 Aug 12;265(5174):956-9 - PubMed
    1. Chem Res Toxicol. 2013 Jul 15;26(7):1073-9 - PubMed
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