Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

doi:10.1016/j.jaci.2016.07.010

Case Reports

. 2016 Dec;138(6):1744-1747.e5.

doi: 10.1016/j.jaci.2016.07.010. Epub 2016 Aug 13.

Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

Gertjan J Driessen¹, Hanna IJspeert², Marjolein Wentink², Helger G Yntema³, P Martin van Hagen², Arthur van Strien², Giorgia Bucciol⁴, Ozgur Cogulu⁵, Margreet Trip², Willy Nillesen³, Els A Peeters⁶, Ingrid Pico-Knijnenburg², Barbara H Barendregt², Marta Rizzi⁷, Jacques J van Dongen², Necil Kutukculer⁸, Mirjam van der Burg⁹

Affiliations

¹ Department of Pediatric Infectious Disease and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
² Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Deparment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
⁴ Department of Women and Children Health, Division of Pediatrics, University of Padova, Padova, Italy.
⁵ Faculty of Medicine, Department of Pediatrics, Division of Genetics, Ege University, Izmir, Turkey.
⁶ Juliana Children's Hospital, Den Haag, The Netherlands.
⁷ Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.
⁸ Faculty of Medicine, Department of Pediatrics, Division of Pediatric Immunology, Ege University, Izmir, Turkey.
⁹ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: m.vanderburg@erasmusmc.nl.

PMID: 27531073
DOI: 10.1016/j.jaci.2016.07.010

Case Reports

Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

Gertjan J Driessen et al. J Allergy Clin Immunol. 2016 Dec.

. 2016 Dec;138(6):1744-1747.e5.

doi: 10.1016/j.jaci.2016.07.010. Epub 2016 Aug 13.

Authors

Affiliations

¹ Department of Pediatric Infectious Disease and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
² Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
³ Deparment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
⁴ Department of Women and Children Health, Division of Pediatrics, University of Padova, Padova, Italy.
⁵ Faculty of Medicine, Department of Pediatrics, Division of Genetics, Ege University, Izmir, Turkey.
⁶ Juliana Children's Hospital, Den Haag, The Netherlands.
⁷ Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.
⁸ Faculty of Medicine, Department of Pediatrics, Division of Pediatric Immunology, Ege University, Izmir, Turkey.
⁹ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. Electronic address: m.vanderburg@erasmusmc.nl.

PMID: 27531073
DOI: 10.1016/j.jaci.2016.07.010

No abstract available

PubMed Disclaimer

Cited by

Monogenic etiologies of persistent human papillomavirus infections: A comprehensive systematic review.
Biglari S, Moghaddam AS, Tabatabaiefar MA, Sherkat R, Youssefian L, Saeidian AH, Vahidnezhad F, Tsoi LC, Gudjonsson JE, Hakonarson H, Casanova JL, Béziat V, Jouanguy E, Vahidnezhad H. Biglari S, et al. Genet Med. 2024 Feb;26(2):101028. doi: 10.1016/j.gim.2023.101028. Epub 2023 Nov 14. Genet Med. 2024. PMID: 37978863 Review.
Current genetic defects in common variable immunodeficiency patients on the geography between Europe and Asia: a single-center experience.
Aygun A, Topyıldız E, Geyik M, Karaca NE, Durmaz A, Aksu G, Aykut A, Kutukculer N. Aygun A, et al. Immunol Res. 2023 Oct 16. doi: 10.1007/s12026-023-09426-9. Online ahead of print. Immunol Res. 2023. PMID: 37840117
Inborn errors of human B cell development, differentiation, and function.
Tangye SG, Nguyen T, Deenick EK, Bryant VL, Ma CS. Tangye SG, et al. J Exp Med. 2023 Jul 3;220(7):e20221105. doi: 10.1084/jem.20221105. Epub 2023 Jun 5. J Exp Med. 2023. PMID: 37273190 Free PMC article. Review.
Incidence, Management Experience and Characteristics of Patients with Giardiasis and Common Variable Immunodeficiency.
Díaz-Alberola I, Gutiérrez-Bautista JF, Espuch-Oliver A, García-Aznar JM, Anderson P, Jiménez P, Hidalgo-Tenorio C, López-Nevot MÁ. Díaz-Alberola I, et al. J Clin Med. 2022 Nov 27;11(23):7007. doi: 10.3390/jcm11237007. J Clin Med. 2022. PMID: 36498582 Free PMC article.
Defining and targeting patterns of T cell dysfunction in inborn errors of immunity.
Campos JS, Henrickson SE. Campos JS, et al. Front Immunol. 2022 Sep 14;13:932715. doi: 10.3389/fimmu.2022.932715. eCollection 2022. Front Immunol. 2022. PMID: 36189259 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
- Ovid Technologies, Inc.
Other Literature Sources
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

Affiliations

Increased PI3K/Akt activity and deregulated humoral immune response in human PTEN deficiency

Authors

Affiliations

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials