Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

J Cataract Refract Surg. 2016 Aug;42(8):1165-72. doi: 10.1016/j.jcrs.2016.07.013.


Purpose: To investigate agreement between the IOLMaster 700 based on swept-source optical coherence tomography (SS-OCT) and the Lenstar LS 900 based on optical low-coherence reflectometry (OLCR).

Setting: Private practice, Castrop-Rouxelle, Germany.

Design: Prospective evaluation of diagnostic test.

Methods: Axial length (AL), keratometry (K), anterior chamber depth (corneal epithelium to lens) (ACD), lens thickness, and central corneal thickness (CCT) were measured in 183 eyes of 183 patients. Analyses used a paired t test, Pearson correlation coefficient (r), and Bland-Altman plots. Intraocular lens (IOL) power calculations were compared using the Hoffer Q, Holladay 1, and SRK/T formulas.

Results: The difference in the mean AL between SS-OCT and OLCR was statistically significant but clinically insignificant (23.61 mm ± 1.27 [SD] and 23.60 ± 1.27 mm, respectively; P < .0001); the agreement and correlation were excellent. The mean K with OLCR was flatter by 0.02 diopter (D) than the mean K with SS-OCT, 43.82 ± 1.43 diopters (D) and 43.84 ± 1.43 D, respectively; the difference was not statistically significant. The mean ACD with SS-OCT was deeper by 0.03 mm than the mean ACD with OLCR, 3.22 ± 0.44 mm and 3.19 ± 0.44 mm, respectively; the difference was statistically significant (P < .001) but clinically insignificant. The differences in the mean lens thickness (OLCR 4.63 ± 0.44 mm and SS-OCT 4.59 ± 0.43 mm) and the mean CCT (OLCR 559 ± 37 μm and SS-OCT 554 ± 36 μm) were not statistically significant. There was no statistically significant difference between the median absolute errors of the 3 formulas.

Conclusions: Agreement between SS-OCT and OLCR was very good. The clinically insignificant but statistically significant differences in AL, ACD, and lens thickness did not reflect a statistically significant difference in IOL power calculation using 3 third-generation formulas.

Financial disclosure: Proprietary or commercial disclosures are listed after the references.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anterior Chamber
  • Axial Length, Eye*
  • Biometry
  • Cataract
  • Germany
  • Humans
  • Interferometry
  • Lenses, Intraocular*
  • Prospective Studies
  • Reproducibility of Results
  • Tomography, Optical Coherence*