Isolation and structure of corazonin, a cardioactive peptide from the American cockroach

FEBS Lett. 1989 Jul 3;250(2):231-4. doi: 10.1016/0014-5793(89)80727-6.


Corazonin, a new cardioaccelerating peptide, has been isolated from the corpora cardiaca of the American cockroach, Periplaneta americana, and its structure determined to be Glp-Thr-Phe-Gln-Tyr-Ser-Arg-Gly-Trp-Thr-Asn-amide. The peptide stimulated heart beat at concentrations as low as 0.2 nM, which makes it the most potent insect cardioactive neuropeptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Cockroaches
  • Heart / drug effects*
  • Insect Proteins*
  • Molecular Conformation
  • Neuropeptides / isolation & purification*
  • Neuropeptides / pharmacology
  • Peptides / isolation & purification*


  • Insect Proteins
  • Neuropeptides
  • Peptides
  • corazonin protein, insect