Skin manifestations of POEMS and AESOP syndrome in the same patient revealing plasma cell dyscrasia

J Cutan Pathol. 2016 Dec;43(12):1167-1171. doi: 10.1111/cup.12798. Epub 2016 Sep 15.

Abstract

POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin signs) and AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) syndromes are rare paraneoplastic conditions due to an underlying plasma cell dyscrasia. We report a 70-year-old patient with the rare coexistence of POEMS and AESOP syndromes and in whom skin signs, that differ both clinically and histologically, were the clues to the diagnosis of a plasma cell disorder. Vascular endothelial growth factor-A overexpression seems to be the common pathogenetic link of the different clinicopathological presentations of the skin lesions.

Keywords: AESOP; POEMS; VEGF-A; glomeruloid hemangioma; plasma cell disorder.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Humans
  • Male
  • POEMS Syndrome / etiology*
  • POEMS Syndrome / metabolism
  • POEMS Syndrome / pathology
  • Paraneoplastic Syndromes / etiology*
  • Paraneoplastic Syndromes / metabolism
  • Paraneoplastic Syndromes / pathology
  • Paraproteinemias / complications*
  • Plasmacytoma / pathology
  • Skin Diseases / etiology*
  • Skin Diseases / metabolism
  • Skin Diseases / pathology
  • Vascular Endothelial Growth Factor A / biosynthesis

Substances

  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A