ATP-dependent chromatin remodeling during mammalian development

Development. 2016 Aug 15;143(16):2882-97. doi: 10.1242/dev.128892.


Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin and, hence, regulate gene expression. These complexes contain diverse subunits that together provide a multitude of functions, from early embryogenesis through cell differentiation and development into various adult tissues. Here, we review the functions of chromatin remodelers and their different subunits during mammalian development. We discuss the mechanisms by which chromatin remodelers function and highlight their specificities during mammalian cell differentiation and organogenesis.

Keywords: Chromatin remodeler; Chromatin remodeling; Differentiation; Gene expression; Transcription.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Animals
  • Chromatin / metabolism*
  • Chromatin Assembly and Disassembly / genetics
  • Chromatin Assembly and Disassembly / physiology
  • Embryonic Development / genetics
  • Embryonic Development / physiology
  • Humans


  • Chromatin
  • Adenosine Triphosphate