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, 22 (9), 1579-86

Ebola Virus Disease, Democratic Republic of the Congo, 2014

Ebola Virus Disease, Democratic Republic of the Congo, 2014

Carolina Nanclares et al. Emerg Infect Dis.

Abstract

During July-November 2014, the Democratic Republic of the Congo underwent its seventh Ebola virus disease (EVD) outbreak. The etiologic agent was Zaire Ebola virus; 66 cases were reported (overall case-fatality rate 74.2%). Through a retrospective observational study of confirmed EVD in 25 patients admitted to either of 2 Ebola treatment centers, we described clinical features and investigated correlates associated with death. Clinical features were mainly generic. At admission, 76% of patients had >1 gastrointestinal symptom and 28% >1 hemorrhagic symptom. The case-fatality rate in this group was 48% and was higher for female patients (67%). Cox regression analysis correlated death with initial low cycle threshold, indicating high viral load. Cycle threshold was a robust predictor of death, as were fever, hiccups, diarrhea, dyspnea, dehydration, disorientation, hematemesis, bloody feces during hospitalization, and anorexia in recent medical history. Differences from other outbreaks could suggest guidance for optimizing clinical management and disease control.

Keywords: Democratic Republic of the Congo; Ebola virus disease; PCR; disease outbreaks; polymerase chain reaction; viruses.

Figures

Figure 1
Figure 1
Survival distribution (Kaplain-Meier) by sex of Ebola virus disease patients admitted to 2 Ebola treatment centers, Lokolia and Boende, Democratic Republic of the Congo, July–November 2014.
Figure 2
Figure 2
Prediction of Ebola virus disease patients’ probability of dying in relation to their Zaire ebolavirus viral load as determined by cycle threshold at admission to an Ebola treatment center, Lokolia and Boende, Democratic Republic of the Congo, July–November 2014.

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