Mangiferin modulation of metabolism and metabolic syndrome

Biofactors. 2016 Sep 10;42(5):492-503. doi: 10.1002/biof.1309. Epub 2016 Aug 18.


The recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt this trend. Natural products have long been and continue to be an attractive source of nutritional and pharmacological therapeutics. One such natural product is mangiferin (MGF), the predominant constituent of extracts of the mango plant Mangifera indica L. Reports on biological and pharmacological effects of MGF increased exponentially in recent years. MGF has documented antioxidant and anti-inflammatory effects. Recent studies indicate that it modulates multiple biological processes involved in metabolism of carbohydrates and lipids. MGF has been shown to improve metabolic abnormalities and disorders in animal models and humans. This review focuses on the recently reported biological and pharmacological effects of MGF on metabolism and metabolic disorders. © 2016 BioFactors, 42(5):492-503, 2016.

Keywords: Mangiferin; hyperglycemia; hyperlipidemia; inflammation; metabolism.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Carbohydrate Metabolism / drug effects
  • Cardiovascular Diseases / drug therapy
  • Diabetes Mellitus / drug therapy
  • Humans
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use
  • Hypolipidemic Agents / pharmacology
  • Hypolipidemic Agents / therapeutic use
  • Lipid Metabolism / drug effects
  • Metabolic Syndrome / drug therapy*
  • Metabolic Syndrome / metabolism
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Xanthones / pharmacology*
  • Xanthones / therapeutic use


  • Anti-Inflammatory Agents
  • Antioxidants
  • Hypoglycemic Agents
  • Hypolipidemic Agents
  • Plant Extracts
  • Xanthones
  • mangiferin