Drug-Induced Tendon Disorders

Adv Exp Med Biol. 2016:920:229-38. doi: 10.1007/978-3-319-33943-6_22.


Drug-induced tendon disorders are an often underestimated risk factor. The range from detrimental effects on the tendon include tendinopathy as well as potentially tendon rupture. As for today, four main drug classes have been reported to be associated with potentially deteriorated tendon properties: 1. Corticosteroids, 2. Chinolon antibiotics, 3. Aromatase inhbitors, 4. Statins as HMG-CoA-reductase inhibitors. Most often, the Achilles tendon is affected in terms of tendinopathy and/or subsequent tendon rupture. However, nearly every tendon of the entire body might be affected in a detrimental way by one or a combination of the aformentioned agents.

Keywords: Adverse effect; Aromatase inhibitor; Chinolon; Corticosteroid; Statin; Tendon; Tendon rupture; Treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / adverse effects*
  • Aromatase Inhibitors / adverse effects*
  • Glucocorticoids / adverse effects*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Tendinopathy / chemically induced*
  • Tendinopathy / pathology
  • Tendons / drug effects*
  • Tendons / pathology


  • Anti-Bacterial Agents
  • Aromatase Inhibitors
  • Glucocorticoids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors