The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction

Acta Odontol Scand. 2016 Oct;74(7):558-564. doi: 10.1080/00016357.2016.1219045. Epub 2016 Aug 19.

Abstract

Objective: We aimed to determine the clinical effects of titanium-prepared, platelet-rich fibrin (T-PRF) on human palatal mucosal wound healing (PMWH) and to identify its effect on time-dependent changes in palatal soft-tissue thickness (PSTT) in terms of histoconduction, which is a new concept.

Materials and methods: Free gingival graft (FGG) donor sites were treated with T-PRF and compared with an untreated control group. The results of colour match and H2O2-bubbling tests for complete wound epithelization (CWE) were recorded on days 3, 7, 14 and 21. Pain level, number of analgesics used and bleeding status were recorded for the first 7 days. PSTT was measured at baseline and after 1 and 6 months.

Results: Colour match scores of the test group were significantly higher than those of the control group at 7 and 14 days. CWE was observed at a higher frequency in the test group than in the control group on day 14. Post-operative bleeding prevalence was lower in the test group than in the control group for the first 2 days. A time-dependent decrease in PSTT was observed at 1 and 6 months in the control group compared with baseline (baseline, 4.23 ± 0.62 mm; 1 month, 4.01 ± 0.68 mm; and 6 months, 3.93 ± 0.69 mm). However, no significant difference was found in the test group (baseline, 4.29 ± 0.64 mm; 1 month, 4.61 ± 0.51 mm; and 6 months, 4.51 ± 0.58 mm).

Conclusion: The T-PRF membrane exhibited positive effects on PMWH. T-PRF, which is a promising autogenous matrix for histoconduction, may also be preferred as an autogenous alternative to connective tissue grafts in the treatment of gingival recessions and peri-implant mucosal recessions.

Keywords: Gingiva; histoconduction; platelet-rich fibrin; tissue transplantation; wound epithelization.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Analgesics / therapeutic use
  • Biocompatible Materials / chemistry*
  • Blood Platelets / physiology*
  • Color
  • Connective Tissue / drug effects
  • Connective Tissue / pathology
  • Connective Tissue / transplantation
  • Fibrin / therapeutic use*
  • Follow-Up Studies
  • Gingiva / drug effects
  • Gingiva / pathology
  • Gingiva / transplantation*
  • Gingival Recession / surgery
  • Humans
  • Hydrogen Peroxide / administration & dosage
  • Oral Hemorrhage / classification
  • Oxidants / administration & dosage
  • Pain Measurement / methods
  • Pain, Postoperative / prevention & control
  • Palate / surgery
  • Postoperative Hemorrhage / classification
  • Prospective Studies
  • Re-Epithelialization / drug effects
  • Titanium / chemistry*
  • Transplant Donor Site / pathology*
  • Wound Healing / drug effects

Substances

  • Analgesics
  • Biocompatible Materials
  • Oxidants
  • Fibrin
  • Hydrogen Peroxide
  • Titanium