A Convenient Palladium-Catalyzed Carbonylative Synthesis of Benzofuran-2(3 H)-ones with Formic Acid as the CO Source

Xinxin Qi; Hao-Peng Li; Xiao-Feng Wu

doi:10.1002/asia.201600873

A Convenient Palladium-Catalyzed Carbonylative Synthesis of Benzofuran-2(3 H)-ones with Formic Acid as the CO Source

Chem Asian J. 2016 Sep 6;11(17):2453-7. doi: 10.1002/asia.201600873. Epub 2016 Aug 19.

Authors

Xinxin Qi¹, Hao-Peng Li¹, Xiao-Feng Wu^{2

3}

Affiliations

¹ Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, 310018, People's Republic of China.
² Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, 310018, People's Republic of China. xiao-feng.wu@catalysis.de.
³ Leibniz-Institut für Katalyse e.V. an der, Universit Rostock, Albert-Einstein-Strasse 29a, 18059, Rostock, Germany. xiao-feng.wu@catalysis.de.

PMID: 27539230
DOI: 10.1002/asia.201600873

Abstract

A general and convenient palladium-catalyzed carbonylation procedure for the synthesis of benzofuran-2(3 H)-ones from phenols and aldehydes has been developed. With formic acid as the CO source, a variety of benzofuran-2(3 H)-ones were obtained in moderate to good yields.

Keywords: CO-free; carbonylation; cascade reaction; heterocycle synthesis; palladium.