The Prevalence of Bipolar Disorders and Association With Quality of Life in a Cohort of Patients With Multiple Sclerosis

J Neuropsychiatry Clin Neurosci. Winter 2017;29(1):45-51. doi: 10.1176/appi.neuropsych.15120403. Epub 2016 Aug 19.

Abstract

Clinical observations of mood instability in multiple sclerosis (MS) have led to the hypothesis that bipolar disorder (BD) may be more prevalent in persons with MS than in the general population. This cross-sectional study assesses the prevalence of BD among patients with MS using standardized psychiatric diagnostic interviews and evaluates quality of life. This study demonstrates a higher prevalence of BD in patients with MS compared with the general population. It also reveals the negative impact of BD on quality of life, raises the concern that BD can occur before the onset of neurological symptoms in MS, and suggests that, in some cases, BD may delay diagnosis of MS.

MeSH terms

  • Adult
  • Bipolar Disorder / complications
  • Bipolar Disorder / epidemiology*
  • Bipolar Disorder / psychology
  • Cohort Studies
  • Comorbidity
  • Cross-Sectional Studies
  • Female
  • Humans
  • Interview, Psychological
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / epidemiology*
  • Multiple Sclerosis / psychology
  • Prevalence
  • Quality of Life*
  • Self Report
  • Tertiary Care Centers