DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes

Jorge Cruz-Reyes; Blaine H M Mooers; Zakaria Abu-Adas; Vikas Kumar; Shelly Gulati

doi:10.14800/rd.1336

DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes

RNA Dis. 2016;3(2):e1336. doi: 10.14800/rd.1336. Epub 2016 Jun 6.

Authors

Jorge Cruz-Reyes¹, Blaine H M Mooers², Zakaria Abu-Adas¹, Vikas Kumar¹, Shelly Gulati²

Affiliations

¹ Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.
² Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

Abstract

Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans.

Keywords: Antivirus ZAP; DEAH-RHA RNA helicase; DXH30; H2F1; Kinetoplastid RNA editing; MOG helicase; MOP-I; REH2; Trypanosoma brucei mitochondria; Zinc finger protein cofactor.

Abstract

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