Acronychiabaueri Analogue Derivative-Loaded Ultradeformable Vesicles: Physicochemical Characterization and Potential Applications

Planta Med. 2017 Mar;83(5):482-491. doi: 10.1055/s-0042-112225. Epub 2016 Aug 19.

Abstract

Elastic and ultradeformable liposomes were synthesized and physicochemically characterized to make suitable topical formulations for delivering the anti-inflammatory and anticancer compound 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid. The average sizes of elastic and ultradeformable liposomes are below 300 nm, while the size distribution and Z-potential are below 0.3 and - 25 mV, respectively. The presence of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid does not affect the physicochemical parameters of nanovesicles. Elastic and ultradeformable liposomes show a zero order release kinetic and are stable at room temperature for a long time with or without 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid. The ultradeformable liposomes are more deformable than elastic liposomes. These differences may depend on sodium cholate derivatives making nanoformulations. The 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid-loaded elastic and ultradeformable liposomes can provide innovative nanotherapeutics-based natural compounds for the potential treatment of cutanous inflammation.

MeSH terms

  • Administration, Topical
  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / pharmacology
  • Diterpenes / administration & dosage*
  • Diterpenes / pharmacology
  • Drug Delivery Systems
  • Drugs, Chinese Herbal / administration & dosage*
  • Drugs, Chinese Herbal / pharmacokinetics
  • Liposomes
  • Propionates / administration & dosage*
  • Propionates / pharmacology
  • Rutaceae / chemistry*

Substances

  • 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid
  • Antineoplastic Agents
  • Diterpenes
  • Drugs, Chinese Herbal
  • Liposomes
  • Propionates