The Association between Hidradenitis Suppurativa and Crohn's Disease: in Search of the Missing Pathogenic Link

Hessel H van der Zee; Barbara Horvath; Gregor B E Jemec; Errol P Prens

doi:10.1016/j.jid.2016.05.102

The Association between Hidradenitis Suppurativa and Crohn's Disease: in Search of the Missing Pathogenic Link

J Invest Dermatol. 2016 Sep;136(9):1747-1748. doi: 10.1016/j.jid.2016.05.102. Epub 2016 Jul 20.

Authors

Hessel H van der Zee¹, Barbara Horvath², Gregor B E Jemec³, Errol P Prens⁴

Affiliations

¹ Department of Dermatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address: h.vanderzee@erasmusmc.nl.
² Department of Dermatology, University Medical Center Groningen, Groningen, The Netherlands.
³ Department of Dermatology, Zealand University Hospital, Roskilde; Health Sciences Faculty, University of Copenhagen, Denmark.
⁴ Department of Dermatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.

PMID: 27542293
DOI: 10.1016/j.jid.2016.05.102

Abstract

Hidradenitis suppurativa is a chronic, autoinflammatory skin disease. Shalom et al. demonstrate in a large cross-sectional study an association between Crohn's disease and hidradenitis suppurativa, but not with ulcerative colitis. This association supports the hypothesis that a similar pathogenic mechanism contributes to both diseases, providing new possibilities for functional studies and therapy development.

Publication types

Comparative Study
Comment

MeSH terms

Adult
Anti-Bacterial Agents / therapeutic use*
Comorbidity
Crohn Disease / drug therapy
Crohn Disease / epidemiology*
Crohn Disease / physiopathology*
Cross-Sectional Studies
Drug Therapy, Combination
Female
Hidradenitis Suppurativa / drug therapy
Hidradenitis Suppurativa / epidemiology*
Hidradenitis Suppurativa / physiopathology*
Humans
Immunosuppressive Agents / therapeutic use*
Incidence
Male
Middle Aged
Prognosis
Risk Assessment
Severity of Illness Index
Treatment Outcome

Substances

Anti-Bacterial Agents
Immunosuppressive Agents