Exposure to bisphenol A and the development of asthma: A systematic review of cohort studies

Reprod Toxicol. 2016 Oct;65:224-229. doi: 10.1016/j.reprotox.2016.08.007. Epub 2016 Aug 16.


Background: There is conflicting evidence about the association between bisphenol A (BPA) exposure and childhood asthma risk. We aimed to review the epidemiological literature on the relationship between prenatal or postnatal exposure to BPA and the risk of childhood asthma/wheeze.

Methods: The PubMed database was systematically searched, and additional studies were found by searching reference lists of relevant articles.

Results: Six studies fulfilled the eligibility criteria. Three studies found that prenatal BPA exposure is associated with an increased risk of childhood wheeze, while another study reported a reduced risk of wheeze. Regarding the postnatal BPA exposure, three studies demonstrated an increased risk of childhood asthma/wheeze.

Conclusions: The mean prenatal BPA was associated with the risk of childhood wheeze/asthma. Besides, the influence of BPA exposure during the second trimester of pregnancy on the prevalence of childhood wheeze was marked. Further studies are urgently needed to explore the underlying mechanism about adverse effect of BPA exposure on childhood wheeze/asthma.

Keywords: Asthma; Biphenol A; Childhood; Systematic review; Wheeze.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Asthma / epidemiology*
  • Benzhydryl Compounds*
  • Cohort Studies
  • Environmental Exposure
  • Environmental Pollutants*
  • Female
  • Humans
  • Maternal-Fetal Exchange
  • Phenols*
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Respiratory Sounds
  • Risk Factors


  • Benzhydryl Compounds
  • Environmental Pollutants
  • Phenols
  • bisphenol A